Online ISSN: 2515-8260

Keywords : C-reactive protein

A Study on C-Reactive Protein as a Diagnostic Parameter in Acute Appendicitis

Naveen Banoth, Venkatesh A .

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 3131-3137

Background: Even though appendicectomy is the most regularly performed emergency surgery, its diagnosis remains uncertain, with a high probability of negative investigations. The study's goal was to investigate the relevance of CRP measurement accuracy in the diagnosis of acute appendicitis and to reduce morbidity by avoiding negative exploration.
Materials and Methods: The present investigation included 30 patients who were clinically diagnosed by surgeons as having acute appendicitis and were sent for an emergency appendectomy at the General Surgery Department, JSS Hospital Mysuru, between the 1st of December 2020 and the 1st of May 2021. Preoperative blood was sent for CRP estimation; postoperative, all specimens were sent for histopathological evaluation; CRP values were correlated with HPE reports to evaluate their function in the diagnosis of acute appendicitis.
Results: In the current study, CRP had the highest sensitivity and specificity of 90% and 80%, respectively, with a positive predictive value of 90%. As a result, it was demonstrated that CRP levels can be used to rule out negative appendicitis, allowing surgery to be postponed in these patients and lowering the rate of negative appendicectomies.
Conclusion: We continue to highlight the importance of a professional surgeon's history and clinical examination in detecting acute appendicitis. CRP, on the other hand, significantly reduces the rate of negative appendicectomy and, as such, should always be included in the diagnostic workup of acute appendicitis

Level of C-reactive protein as a predictor for preterm deliveries

Dr Sangam Padma, Dr Bukke Soujanya

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 10248-10256

Background: CRP measurement is quick, non-invasive, and risk-free that can be a
useful diagnostic test for evaluating and categorizing the risk levels and also
anticipating the morbidity of both mother and fetus.
Aims: To identify the association between the level of C-Reactive protein (CRP) with
preterm deliveries.
Materials and methods: It is Hospital based Prospective Observational study done for a
period of 2 Years in 95 pregnant women with gestational age between 24 weeks to 36
weeks+6days, who present to emergency /labor room with regular uterine contractions,
at least four in 20 minutes or eight in 60 minutes in presence or absence of cervical
changes.Patients were then followed up till 7 days for preterm delivery. Further
categorization of subjects was done into 2 groups:Group 1: Those who delivered
preterm within 7 days of admission.Group 2: Those who did not deliver within 7 days of
Results: 95 patients with premature uterine contractions were analysed for CRP levels
and were followed up to find out if they underwent preterm delivery within 7 days of
admission. The mean value of CRP was calculated in the 2 groups and was found to be
higher in those who delivered within 7 days with a statistically significant p value 0.001.
The curve generated cut off for CRP was ≥3.55 mg/l (AUC 0.809, SE 0.046, P <0.001),
indicating a positive association for preterm delivery. With the derived cut off, the
sensitivity, specificity, positive predictive value, negative predictive value of CRP for
predicting preterm delivery was found to be 80.4 %, 75.5%, 80.7% and 75.2%
respectively, with diagnostic accuracy of78.3%.
Conclusions: Prediction of preterm delivery by a simple biomarker like CRP could help
in early intervention and subsequentprevention of preterm birth and its sequelae.

Prognostic significance ofProcalcitonin, High sensitivity C-reactive proteinandwhite blood cell count incomparison withblood culture in ICU patients with Sepsis and Septic shock inatertiary care Hospital

Dr.Kondle Raghu; Dr. Krishnan Ramalingam

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 2263-2270

Background: Sepsis is a life-threatening condition in ICU with high morbidity and
mortality. Biomarkers which can act as a predictor for diagnosis, prognosis, and patient
outcome in sepsis are needed.
Aim:Aim of the study is to compare the significance of hs-C-reactive Protein (CRP),
Procalcitonin, White blood cell count, and blood culture in patients with bloodstream
infections and compare their prognostic significance with blood cultures in sepsis.
Materials and Methods: This hospital based prospective observational study was conducted
between July 2018 to July 2019 forone year with 216 cases of sepsis. Serial determination
of Procalcitonin and CRP at admission and Day 6 was done. Data was analyzed check to
compare the prognostic significance of the PCT, CRP, and WBC count.
Results:A blood culture positivity rate of 50.9% was reported with male preponderance.
WBC count has significantly reduced after 72hrs of admission (p= 0.007). CRP levels have
significantly reduced on day 6 (p = 0.043) in comparison to at the time of admission (p=
0.032). The serial determination of PCT levels at admission and on day 6 (p= 0.032) was
found to be a better prognostic indicator in patients with sepsis than at the time of
admission. The significant patient outcome in terms of mortality and reduction in length of
hospital stay has been found (p= 0.018, p=0.002). The positive correlation of PCT and CRP
and SOFA score has been reported.
Conclusion: Prognostic significance was found for the biomarkers PCT, CRP, and WBC
count with significant patient outcomes in terms of mortality and hospital stay reduction

Neurological disorders in patients underwent COVID-19

Nargiza Nasriddinovna Ergasheva; Dilbar Nabievna Khidoyatova; Yakutkxon Nabievna Madjidova; Yuldasheva Manzura Muchammad Tofik kizi; Zulfiya Amalgeldievna Xodjaeva

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 256-262

Introduction: COVID-19 is the current global coronavirus pandemic caused by the SARS-CoV-2 coronavirus. The first reports of the disease outbreaks appeared in China on December 31, 2019 and the first clinical manifestations occurred earlier on December 8, 2019. On January 30, 2020, the World Health Organization declared the outbreak as a public health emergency of international concern. On March 11 it was declared a pandemic. Common symptoms include fever, cough, fatigue, shortness of breath, and anosmia (loss of smell).Complications can cause acute respiratory distress syndrome (ARDS) and pneumonia. The incubation period is usually around five days, but can range from two to fourteen days.
Aim of the research isto study of clinical and diagnostic criteria for neurological disorders and changes of laboratory parameters in patients with COVID-19.
Material and methods: We examined 31 patients who had undergone COVID-19 and were hospitalized at the private clinic "Neuromed-Service" named after academician N.M. Madjidov. There were 19 males and 14 females. The age of the patients varied from 18 to 75 years (the mean age made up 41 years).
Results: Patients with inflammatory diseases of the peripheral nervous system (neuropathy, facial nerve, trigeminal neuralgia), considering an increase of C-reactive protein were performed anti-inflammatory therapy with NSAIDs and steroids (Dexamethasone intramuscularly). In patients with convulsive syndrome EEG was monitored using the "Neuron - range 2" (Russia). Diffusechangesinthebioelectricalactivityofthecerebralcortexwererevealedinthestudiedpatients.Epiactivityinthefronto-parietalregionofthebrain (against the background of taking anticonvulsants)was also recorded. The dose of anticonvulsants was increased for these patients and decongestants were prescribed. An increase in fibrinogen was also noted in the blood of these patients. Conclusion: Thereby, in patients after suffering COVID-19, the blood tests showed an increase of fibrinogen by more than 2 times and an increase of C-reactive protein. All this testifies the fact that in these patients after treatment, at the alleged improvement of their condition, the blood continued the process of thrombosis strengthening and inflammation persisted in tissues and organs. In patients who prematurely stopped taking antiplatelet agents and anti-inflammatory drugs after illness, neurological and other complications were developed

The Dynamics of C-reactive Protein Associated with Nutritional Status Changes in Kidney Failure Patients at Initiation and After 3 Months of Dialysis

Trina Primalia Irawanti; Haerani Rasyid; Syakib Bakri; Hasyim Kasim; Andi Makbul Aman; Fabiola Maureen Shinta Adam; Nur Ahmad Tabri; Arifin Seweng

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 152-159

Among kidney failure patients, especially those on dialysis, malnutrition is associated with poor outcomes. Malnutrition is a multifactorial process, including inflammation, which can be measured by C-reactive protein (CRP). The objective is to evaluate the dynamics of CRP associated with nutritional status changes in kidney failure patients at initiation and after 3 months of dialysis. A prospective cohort study using a consecutive sampling method consisting of 40 kidney failure patients who received initial dialysis at Dr. Wahidin Sudirohusodo Hospital, Makassar, Indonesia from January-March 2020. Nutritional status was evaluated with Subjective Global Assessment (SGA), and CRP was measured at the initial dialysis and after 3 months. All subjects received nutritional education at the beginning. Nutritional status was defined as well-nourished (WN, SGA A) and malnourished (MN, SGA B and C), then classified into 4 groups denoting nutritional changes: Group 1 (WN to WN), Group 2 (MN to WN), Group 3 (WN to MN), and Group 4 (MN to MN). ANOVA, paired t-test, and chi-square test (significance p<0.05) were used for statistical analyses. Subject’s mean age was 50.5±14.8 years old; 52.5% were male. Diabetes and obstructive nephropathy were the most frequent underlying diseases, both had a prevalence of 35%. At initiation, the prevalence of malnutrition was 77.5%; after 3 months, it was 70%. The highest proportion of Group 4 were female (62.5%) and those with diabetes (45.9%). Among all subjects, mean CRP decreased (9.4±32.3 mg/dL) after 3 months. While mean CRP based on nutritional changes, Group 2 had the highest reduction (18.8±26.8 mg/dL), and Group 3, CRP increased (17.5±17.0 mg/dL). C-reactive protein is negatively associated with nutritional status changes in kidney failure patients after 3 months of dialysis. Malnutrition was higher in female subjects and those with diabetes.