Most thyroid lesions present as benign swellings which require fine needle aspiration for diagnosis. Fine needle aspiration cytology (FNAC) and serological methods can both be used to identify the alterations occurring at the cellular level. The recent epidemiological trends of benign thyroid lesions seen at a tertiary care centre in Pune, India were identified. FNAC (fine needle aspiration cytology) and serological tests were used to diagnose the thyroid lesion and the results were correlated. Patients with probable benign thyroid illness who presented to the outpatient department were sent for FNAC (fine needle aspiration cytology) and the smears were stained with hematoxylin and eosin. 2 to 5 cc of blood was aspirated into a red-capped vacutainer and analysed using chemiluminescence principle and ELISA (enzyme linked immuno sorbent assay)for thyroid function test. There were 76 patients enrolled in the study, with 17% men and 83% women. The age range of 45 to 60 years saw the highest number of instances. The thyroid profile revealed 37 euthyroid patients, 19 hypothyroid cases, and 20 hyperthyroid cases. 12 out of 14 subjects with thyroid swelling diagnosed as single nodular goitre was having euthyoid status while 7 out of 9 diagnosed as multinodular goitre were having hyperthyroid status. Eight of the cases of Hashimoto's thyroiditis 5 cases were hypothyroid, while 1 instances was euthyroid, 2 cases were hyperthyroid. As opposed to lymphocytic thyroiditis, which had 5 euthyroid, 4 hypothyroid, and 1 hyperthyroid patients. There was no discernible relationship between thyroid hormone levels and FNAC (fine needle aspiration cytology) results when they were compared. In light of this situation, separate and individual assessments of thyroid hormone levels and FNAC (fine needle aspiration cytology) are required for accurate evaluation.