Online ISSN: 2515-8260

Keywords : Albumin

Comparative Evaluation And Correlation Of Various Clinical Parameters In Chronic Kidney Disease Patients With Or Without Hemodialysis: An Original Research Study

Dr. Himadri Shankar .

European Journal of Molecular & Clinical Medicine, 2023, Volume 10, Issue 1, Pages 1867-1872

Background & Aim: Most of the early kidney diseases do not represent any clinical symptoms therefore left undetected. Chronic kidney disease is characteristically identified by usual testing of blood serum. Advanced cases of chronic kidney disease also manifest with some peculiar symptoms fatigue, loss of appetite, nausea, vomiting, metallic taste, inadvertent weight loss. This study was conducted to compare and correlate various clinical parameters in chronic kidney disease patients with or without hemodialysis.
Materials and Methods: The study was conducted over a year time on 80 chronic kidney disease patients. 45 male and 35 female patients in the age range of 30 to 50 years were studied in detail. Parameters and factors associated to chronic kidney disease were considered; Serum Cholesterol, Triglycerides, High Density Lipoproteins, Low Density Lipoproteins, Albumin (urine), Creatinine. Albumin is a type of proteins seen in blood normally. Group 1 patients consisted of 40 patients who underwent hemodialysis procedure. Group 2 patients consisted of 40 patients those have not undergone hemodialysis procedure. All data was forwarded for statistical analysis for further investigation and interpretations. P value less than 0.05 was taken as significant.
Statistical Analysis & Results: Statistical analysis was done by using software statistical package for the Social Sciences In group 1, mean Serum Cholesterol level was 179.41 (mg/dl) while mean Triglycerides level was 133.26 (mg/dl). P value was highly significant (0.01) for Serum Cholesterol level. In group 2, the mean Serum Cholesterol level was 201.41 (mg/dl) while mean Triglycerides level was 165.36 (mg/dl). P value was highly significant (0.02) for Serum Cholesterol level. Mean Albumin and mean Creatinine was 29.22 and 1.44 respectively. One-way ANOVA analysis of both study groups revealed highly significant p value.
Conclusion: Authors concluded that chronic kidney disease patients without hemodialysis exhibit deleterious discrepancies of tested lipid parameters (Dyslipidemia). Nevertheless, Albumin and Creatinine levels are also increased in chronic kidney disease patients (without hemodialysis). Accordingly chronic kidney disease patients without hemodialysis are at higher risk of possibility of blocked arteries and other related dilemmas.

Cord blood albumin as a predictor of significant neonatal hyperbilirubinemia in normal term healthy newborn

Dr. Dharmagadda Sai Krishna, Dr. Hemant Gupta, Dr. Neelam Grover, Dr. Bharti Kawatra, Dr. Kiranjeet Kaur

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 18-24

Introduction: Hyperbilirubinemia is the most common morbidity in normal term healthy
newborn. There is evidence that cord blood albumin (CBA) level can act as a potential marker
for the prediction of hyperbilirubinemia in neonates. The present study was therefore designed
to establish a correlation between the level of cord blood albumin (CBA) and total serum
bilirubin (TSB) so that albumin level could be standardized as a prediction marker for the
neonatal hyperbilirubinemia.
Methods: CBA and TSB levels were analysed in 500 normal term healthy newborns with birth
weight ≥2500 grams and APGAR score ≥ 7/10 at 1 min and 5 mins, after obtaining consent
from their parents. Albumin levels were analysed from the cord blood at the time of birth and
TSB levels were analysed from venous blood. Pearson’s correlation coefficient was used to
analyse the correlation between CBA and TSB levels.
Results: The mean CBA was 2.94 ± 0.34 g/dl and mean TSB was 11.17 ± 2.52 mg/dl. The
relationship between CBA and TSB values was statistically significant on further analysis of
CBA with the modality of treatment, the results were again statistically significant. The
correlation between CBA and TSB was also observed with negative correlation of r = - 0.43
with p value of <0.0001 which was highly significant.
Conclusion: Newborns with high CBA levels have low risk of developing neonatal
hyperbilirubinemia and can be discharged early from hospital. Whereas low CBA is an
indicator for developing neonatal hyperbilirubinemia in the first week of life.


Dr. Nitin N. Jadhav ,Dr.Mrs. Patange Aparna , Dr. Virendra C. Patil

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 1557-1571

With the help of clinical and biochemical tests, we will evaluate the relative benefits of Terlipressin in combination with albumin against albumin alone for treating hepatorenal syndrome. The eighty patients were divided evenly. Albumin was the sole treatment for Group 1, whereas Terlipressin was added to the mix for Group 2. The information was analysed with IBM SPSS 20. The tables were made using a combination of a frequency distribution and a cross-tabulation. The data is presented with a mean, standard deviation, and median (minimum–maximum). Student's t and Mann–Whitney tests were employed to compare continuous variables. “Analyzing categorical data with the Pearson Chi square and Fisher's exact test Less than 0.05 was considered statistically significant. The non-significant p value of 0.79 reveals no difference in etiology distribution between treatments. With the exception of SGOT (p = 0.002), which was lower in the Terlipressin + albumin treatment group (61.89± 47.83) than albumin alone, total bilirubin, SGPT, INR, and serum albumin were all the same in both groups (96.80±109.30). Terlipressin and albumin reduced serum creatinine. Serum creatinine dropped 50.14 percent (1.73 ± 1.49) from day 1 (3.47 ±1.68) to day 5. Albumin patients fell 9.33%. Serum creatinine decreased in the albumin group (p = 0.237)”. Every measure, with the exception of SGOT, which was much lower in the Terlipressin plus albumin treatment group and may indicate a better safety profile, was equivalent in both groups, including total bilirubin, SGPT, INR, and serum albumin. Blood creatinine levels upon admission and on day five revealed that patients who took Terlipressin with albumin fared better in terms of their health and biochemistry.


Javkharov Oybek Zulfiqorovich; Amirov Shavkat Kuzibaevich; Sobirov Ilhom Abdullaevich; Karimov Sherali Allaberdievich; Esonov Hasanboy Abdumutallibovich

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 9, Pages 1959-1965

The experiment examined the effect of the use of Introvit A + WS-amino acidvitamin
nutrient mixture in the diet of dairy cows on the efficiency of milk production. The use of
Introvit A + WS-amino acid-vitamin in the diet resulted in an increase in milk productivity due to
balancing the protein-energy ratio in cows, an increase in milk fat and protein content, and a 5%
reduction in feed consumption due to efficient cow nutrition.

A Study on the Phytochemical analysis of Tarlmouniaelliptica (DC.) "H.Rob., S.C.Keeley, Skvarla&R.Chan"

Bharathkumar A.; Vijayaraj R.; Madeena Begam S.; JaqulineChinna Rani I.

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 3195-3209

Plants, acting as an essential source of nutrients and medicinal ingredients, have long
been known for their natural arsenal. Human beings have used plants as medicinal items for
around 600,000 years. The preparations released from certain plants lead to plant medicines.
Today, plant medicines are popular worldwide, where herbs are used as primary medicines
by around 80% of the world’s population. This medicinal importance is primarily due to the
richness of bioactive phytochemicals in plants.
In this study, we aimed at screening the phytochemicals and biological activities of
Tarlmouniaelliptica(DC.) Fresh leaves, derived from plant material, were dissolved in four
different solvents methanol, chloroform, benzene and distilled water. The phytochemical
composition of extracts showed the presence of alkaloids, phenolics flavonoids and
terpenoids. DPPH radical scavenging and Fe2+ chelating activity assays and
Phosphomolybdenum assay were used to assess the antioxidant potential. The antiinflammatory
potential was evaluated by analyzing the Inhibition of albumin denaturation.
Biological activity of extract such as anti-diabetic and anti-fungal activity was also tested and
the result showed maximum activity of plant species.
Collectively, our observations suggest a promising potential for
Tarlmouniaelliptica(DC.) during the treatment of diseases associated with oxidative stress,
aberrant inflammatory responses, and glucose-sugar control. However, further experimental
procedures are needed to support this postulate.

The Role Of Biologically Active Substances In The Blood In Increasing The Productivity Of Sheep

Shavkat Mukhitdinov; Dilmurod Aliyev; Komil Ismoilov; Gulnora Mamurova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 2704-2710

Physiological, immunogenetic, selection, technological, biotechnological, and other methods to increase the productivity of karakul sheep are used to increase their productivity, as well as biologically active substances that increase the productivity of karakul sheep.