Online ISSN: 2515-8260

Keywords : subclinical hyperthyroidism


STUDY OF PREVALENCE & FETO-MATERNAL OUTCOME IN THYROID DISORDERS COMPLICATING PREGNANCY IN A TEACHING HOSPITAL

M Sowbhagya Laxmi, Manisha Jain, Sara Khaja Syed Abdul Basheer

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 2862-2874

Background: Pregnancy is commonly associated with thyroid disorders which have an impact on the fetal and maternal outcome. Among the various thyroid disorders, hypothyroidism is the commonest. There is a wide geographic variation in the prevalence of hypothyroidism. It varies from 2.5% in the west to 11% in India. Prevalence of hypothyroidism was found to be more in Asian countries compared with the west. Therefore the present study was carried out to study the prevalence of thyroid disorders in pregnancy in our hospital. To study the prevalence and fetal and maternal outcome in thyroid disorders complicating pregnancy in a teaching hospital.
Materials and Methods: Prospective observational study was done in the department of Obstetrics & Gynaecology at Shadan Institute of Medical Sciences and Research Centre for duration of one year i.e., (April 2021- March 2022) which included thousand pregnant women.
Results: In our study, the prevalence of thyroid disorders was 10.6%. The incidence of Subclinical hypothyroidism was 9.1% and Overt Hypothyroidism was 1.1%, Sub-clinical hyperthyroidism was 0.3% and Overt Hyperthyroidism was 0.1%. The incidence of Pre-eclampsia was 15.09%, Anaemia 16.04%, Pre- term delivery 9.43%, LBW 11.32%, IUFD 2.83% and Caesarean deliveries 15.09% in 106 pregnant women with thyroid disorders.
Conclusion: Our study showed high prevalence of thyroid disorders 10.6%. Thyroid disorders in pregnancy are significantly associated with fetal and maternal complications. Universal screening of pregnant women for thyroid disorders should be considered in a country like India where there is a high prevalence of undiagnosed thyroid disorders.

Assessment of thyroid functions in early pregnancy

Dr Ramakant Rawat, Dr Vijay Kumar Verma, Dr Rajani Rawat, Dr. Amit Varshney, Dr Anima Dayal

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 2090-2095

Background: Measurement of serum free T4 concentrations and TSH is helpful in
assessing thyroid function. During the first trimester of pregnancy, free T4 levels
measured by analog immunoassays may be unreliable, as measurements using 2
different assays were not reproducible. The present study was conducted to assess
thyroid functions in early pregnancy.
Materials & Methods:
Results: Age group 18- 21 years had 28, 22-25 years had 25, 26- 29 years had 20 and 30-
33 years had 7 patients. Subclinical hypothyroidism was seen in 20, euthyroidism in 4,
overt hypothyroidismin 8, subclinical hyperthyroidism in 45 and overt hyperthyroidism
in 3. The mean TSH (mIU/l) in subclinical hypothyroidism was 4.31, in euthyroidism
was 1.48, in overt hypothyroidism was 10.32, in subclinical hyperthyroidism was 0.016
and in overt hyperthyroidism was 0.06. The mean FT3(pg/ml) level in subclinical
hypothyroidism, euthyroidism, overt hypothyroidism, subclinical hyperthyroidism and
overt hyperthyroidism was 4.08, 3.94, 1.54, 4.2 and 7.52 respectively. The mean
S.FT4(ng/dl) level in subclinical hypothyroidism, euthyroidism, overt hypothyroidism,
subclinical hyperthyroidism and overt hyperthyroidism was 1.20, 1.28, 0.48, 1.6 and 4.2
respectively.
Conclusion: The high prevalence of thyroid disorders in pregnant women makes it
necessary to screen all the pregnant women in early pregnancy.