Online ISSN: 2515-8260

Keywords : brain tumors

VEGF-A, VEGFR-2 and MVD in brain tumor tissue

Agnieszka Nowacka; Wojciech Smuczyński; Maciej Śniegocki; Kamila Woźniak- Dąbrowska

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 1180-1187

Neoangiogenesis plays a crucial role in tumor development. The method that is most commonly recommended for assessing this process is determining the so-called microvessel density (MVD) in the tissue sample. In relation to tumors of the central nervous system, it seems that VEGF-A along with its receptor VEGFR-2 are the most significant factors, and the important role of both of them is connected with their increased expression in tumor tissue. The study concerned 48 adult patients of both genders, treated surgically for newly diagnosed solid brain tumors andconsisted of histological assessment of the material gained from the surgically removed brain tumor. The highest level of VEGF in tumor tissue was observed in gliomas – mostly HGG - 12.61 (N = 23, p = 0.000059). As for VEGFR-2 in tumor tissue, the highest average level was characteristic for metastatic tumors - 13.67 (N = 6, p = 0.037) and it was slightly lower in HGG - 12.2 (N = 23, p = 0.037). The average MVD in tumor tissue was the highest in HGG - 20.13 (N = 23, p = 0.047) and other tumors - 18.33 (N = 3, p = 0.047). The remaining types of tumors in the studied group had similar microvessel density – from 13.67 to 14.71.