Online ISSN: 2515-8260

Keywords : Hyperthyroidism


Pregnancy Outcome in Thyroid Disorder -A Clinical Study

Neelima Varaganti, Himabindu Sangabathula, Anatalaxmi Porla

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 844-854

Background: The objectives is to Screening of all the antenatal pregnant women for
thyroid dysfunction, To study the maternal and fetal noutcome in pregnancy thyroid
dysfunction, To provide adequate treatment and there by reduce adverse outcome,
Follow up of cases six weeks post partum.
Materials and Methods: Prospective, observational study. 110 patients were included.
The study was conducted at Department of Obstetrics and Gynecology (OBG), Modern
Govt MaternityHopsital, Petlaburz attached to Osmania Medical College, Hyderabad,
Telangana, India during the period from 1st December 2019 to 30th June 2021.Mothers
attending for ante-natal check-up and having either a detected or documented thyroid
dysfunction. An Institutional Ethics Committee approval was obtained. Written
informed consent was obtained from all the study participants. The mothers during
their first visit were included for detailed history, clinical examination and blood
investigations as follows.
Results: No age related influence in the presence of thyroid dysfunction, there was no
statistical significance. it was observed that 68% of abortions were in primigravida, it
was found that with increase in gravida abortion rate was less. the mode od delivery
had no significant variations in both hypo/hyperthyroidism. it was noted that
subclinical hypothyrid and overt hypothroid cases resulted in more preterm deliveries
than hyperthyroid patients.the study showed no significance difference in newborn
thyroxine levels among thyroid dysfunction groups.
Conclusion: The study showed that thyroid dysfunction is more among the pregnant
women. Hypothyroidism is the major thyroid dysfunction among the antenatal women.
The women with thyroid dysfunction had more incidents of adverse outcomes of
pregnancy like increased abortion rates, caesarean deliveries on the mothers and
preterm babies and lbw on the newborn.

Assessment of thyroid dysfunction among different psychiatric disorders

Dileep Singh Verma, Bhagyashree Garasia, Amrit Ku Gausai, Suresh Gocher, Sushil Kherada

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 2301-2308

Thyroid hormone abnormality is mutual in foremost psychiatric disorders. Thyroid hormones play critical function in the method of Neurogenesis and Neurodevelopment i.e., Myelination, dendrite proliferation and formation of synapses. There is link among thyroid axis and several experienced psychiatric disorders. Noteworthy results on cerebral thyroid characteristic are observed while there are even small variations in thyroid hormone levels, within the normal range. Alterations in mood, behaviour and cognition are resulting from this. Depression, psychosis and cognitive disorder are observed in the patients of hypothyroidism. Meanwhile, people with hyperthyroidism had been observed to have psychosis, aggression, anxiety as well as cognitive impairment. Memory impairment is related with Subclinical hypothyroidism.
The objective of this study was to analyse the socio-demographic profile with assessment and comparison the type of thyroid dysfunction among patients with major psychiatric disorders. This was a cross-Sectional Observational study on 166 patient samples. Assess serum thyroid stimulating hormone (TSH), T3 (triiodothyroxine), T4 (L-thyroxine), free unbound fractions of T3 and T4 (FT3 and FT4) with the COBAS e 411 ANALYSER at Kalpana path lab, R.M.R.S.M.B. govt. hospital, Udaipur for all recruited patients.
Result of our study is that thyroid dysfunction occurs significantly in patients with psychiatric disorders. Subclinical hypothyroidism was the most common abnormality observed in the study population. Thyroid dysfunctions were predominant in females. Most of the cases with thyroid dysfunction were from rural area and age group 41-50 years. In present study, 25% of total cases drug naïve for ≥ 6 months and 10.6% of total new cases had thyroid dysfunction. Most of the cases with thyroid dysfunction were related to F20-F29 block. Isolated increased FT4 level found in significant proportion of population. This is a useful finding as this calls for frequent monitoring of Thyroid function tests in all psychiatric patients on treatment, to enable proper management.

ASSOCIATION BETWEEN SERUM ZINC-ALPHA-2-GLYCOPROTEIN WITH THYROID HORMONE IN NEWLY DIAGNOSED HYPERTHYROIDISM

Ahmed Nofal Ali, Ihab Mohamed Salem, Atef Gouda Hussein, Mohamed Gaber Hamed

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 4669-4678

Background: Thyroid dysfunction may contribute to lipids metabolic disorders. Zinc-alpha-2-glycoprotein (ZAG) function comes from its specific lipolytic action.  This study aimed to find the association of serum ZAG levels with thyroxin and lipid profile in patients with hyperthyroidism before and after carbimazole treatment. Patients and methods: This study was conducted as a case-cohort study done on 23 patients suffering from typical symptoms of hyperthyroidism. In addition, 23 apparently healthy individuals were chosen as a control group. All patients were selected from Internal medicine department, Zagazig University Hospitals. Results: The present study showed fasting plasma glucose levels and SBP were significantly higher among case group. The difference in lipid profile in case group before and after treatment with carbimazole.There was significant higher levels in total cholesterol and TG Levels after treatment. The difference in lipid profile in case group before and after treatment with carbimazole. There was significant reduction in HDL Levels after treatment. While LDLwas significant higher after the treatment. Significant reduction in ZAG levels after treatment with carbimazole in case group. Conclusion: ZAG has a novel role in lipid metabolism as it has specific lipolytic action so it has a potential role in body weight regulation, protect against fatty liver by ameliorating hepatic steatosis, insulin resistance and inflammation.

Assessment of cardiovascular manifestations of hyperthyroid disorder patients

Dr.Mayank Panwar,Dr.Akanksha,Dr. Bijoy Jyoti Saikia, Dr.Peddi Shreya

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 11, Pages 9414-9417

Background: Hyperthyroidism is defined as excess concentration of thyroid hormones
in the body due to either increased synthesis of the thyroid hormone, increased release
of preformed thyroid hormones, or from endogenous or exogenous extrathyroidal
sources. The present study was conducted to assess cardiovascular manifestations of
hyperthyroid disorder patients.
Materials & Methods: 104 patients of hyperthyroidism of both gendersunderwent
clinical evaluation, basic laboratory tests like CBC, RFT, LFT and ECG and 2D ECHO
were performed in these patients to evaluate the presence of any cardiac manifestations.
Results: There were 34 males and 70 females. Age group upto 40 years had 20, 41-60
years had 34 and >61 years had 50 patients. Common symptoms were pallor in 90,
edema in 86, moist skin in 74 and eye signs in 53. Cardiovascular symptoms recorded
were chest pain in 82, palpitations in 95 and breathlessness in 60. Among 104 patients,
ECG changes were seen in 42 patients. Out of this, sinus tachycardia was seen in 65%,
AF in 10%, ST T changes in 6%, RVH in 7%, LVH in 11% and RBBB in 5%. The
difference was significant (P< 0.05).
Conclusion: Cardiovascular manifestations are quite common in hyperthyroid patients.

Effects of Infection with Toxoplasma Gondii to the Levels of Thyroid Hormones

Taghreed Ahmed Mustafa Al-Issawi; Aysir Saleh Mohammed

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 110-114

The present study was designed to detect the effect of toxoplasmosis in the thyroid hormones level Samples were collected during the period from July2019 to January 2020. Where the separated serum was preserved at a temperature (-20) until use. The enzyme-linked immunosorbent technique (ELISA) was used to detect toxoplasmosis. Hormone levels (TSH, TSH, T3 and calcitonin) were also measured using ELISA technology, Hormonal study, the results of the current study showed significant increase (P