Topical drug delivery system has a separate place among various conventional drug delivery systems, due to its popularity because providing of different beneficial approaches likeavoiding fast pass mechanism, surpassing gastrointestinal irritation, metabolic degradation associated with oral drug delivery systems. The topical delivery system otherwise known as the dermatological system is one that applied directly to any external body surface byinunctions (by spreading or rubbing), or by spraying or dusting it on, or by instilling it. Topical drug delivery systems used when other drug delivery system does not show desired efficacy. Topical drug delivery system, in most of the cases designed to implement through the skin. The human skin is the defensive shield which protects us from the biological environment surrounds us. Skin which is an easily accessible organ in the human body due to its major and direct linkage with bloodstream through a highly complex network of capillaries, arterioles and arteries connected to it, is an ideal and preferred site of applications of topical drug delivery. The topical drug delivery system is used to exert a local effect for treating skin disorder or as a tool for delivering drug systemically to produce systemic effects by reaching out targeted tissue. Major groups of solid to semisolid preparations are exploring to use as topical drug delivery systems includes ointments, creams, gels, pastes, aerosols, solutions, etc [1, 2, 5].