Background: To assess the effect of Proton Pump Inhibitors on renal profile. Materials & methods: A total of 100 subjects were enrolled. The age of subjects included was between 18 to 70 years. Values of blood urea and serum creatinine were taken twice, first before start of therapy and then after at least one week of therapy. Results: The subjects with AKI present were 11 out of the total. The age wise distribution of the incidence of AKI was more in the population over 50 years, with the maximal incidence in the group above 51 years. Conclusion: Prescription of PPIs in AKI should be monitored.