This study investigated the influence of work stress and occupational productivity among academic staff of universities in Cross River and AkwaIbom States, Nigeria. To achieve the purpose of this study, two research questions were raised to guide the study. Related literature was reviewed. Expost facto research design was adopted for the study. The stratified random sampling technique was employed and a sample size of 639 academic staff was used for the study. Work Stress and Occupational Productivity of Academic Staff Questionnaire (WSOPASQ) was used for data collection. Data collected were analyzed using one-way analysis of variance (ANOVA) to test the two null hypotheses at 0.05 level of significance. The findings revealed that role ambiguity has a significant influence on teaching but not significant in terms of research and community service. Working environment has a significant influence on teaching and research but not significant in terms of community service. The study recommended among others that university management should provide adequate facilities such as staff offices, lecture halls, equipment, materials, this is to ensure that academic staff has the tools and technology to work to their full potentials. Academic staff should undergo proper orientation and monitoring in order to have adequate information about the demands and job roles.