Abstract: Objective: To test the diagnosis of oral leukoplakia with diode laser. Materials & methods: Throughout this investigation we found five cases of oral leukoplakia that were validated through biopsy then diagnosed using laser diode. Results: Diode laser offers pain free and fast tissue repair resulting from the procedure. The time of recovery lasted from 7 days to 30 days well after laser cure and no resection from 2 years well after research. Conclusions: The diode laser seems to be an effective means of handling contaminated wounds and helps avoid malignancy by treating oral leukoplakia.