ABSTRACT Silver diamine fluoride is an anticariogenic agent. This intervention can be applied to teeth as soon as caries is detected. It is well known for arresting active carious lesions painlessly, without the use of local anesthetic as long as the teeth are asymptomatic, thereby avoiding or delaying traditional surgical removal of caries. It has a wide range of applications in dentistry with certain contraindications. Adverse events using silver compounds have not been reported in more than 80 years. This paper emphasizes on when and where to use and not to use SDF therapy.