Background: Myocardial infarction also known as acute myocardial infarction (AMI) term, which is commonly used for an event of heart attack. The biomarker is possible of using different hsCRP & lipids biochemical marker for predicting risk of myocardial infarction (MI). Objectives: Utility of high sensitivity C-reactive protein and Lipid Profile levels in Myocardial Infarction. Patients and Methods: Evaluation of biochemical marker and examined by the cardiologist of confirming myocardial infarction patients and healthy control of all age groups from the period of January 2018 to December 2019. This study divided into two groups: group A: 55 Myocardial Infarction patients; group B: 55 healthy control subject. Comparison between lipid profiles & High sensitivity C Reactive Protein, including serum total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides, in 55 myocardial infarction patients. Patients included 29 (52.8%) STEMI patients, 4 (7.2%) NSTEMI patients and 22 (40%) patients with chest pain. Control group age and gender-matched normal subjects are included. Results: The levels of lipid profile and hsCRP in case and control subjects were significant (p value= 0.0001**) high in the myocardial infarction patients. Myocardial infarction patients had significant higher levels of hsCRP, TC, LDL, VLDL, TG, LDL/HDL, TC/HDL and decreased level of HDL as compared to the control subjects. Conclusions: Elevated hsCRP has a strong significant association with lipid profile in myocardial infarction. These data suggest that inflammatory processes play a self-regulating role in the pathogenesis of myocardial infarction.