ABSTRACT: Silk fibroin (SF) is generally termed as the protein-based bio-macromolecule, with exceptional biodegradability, biocompatibility, and poor immunogenicity. Because of higher bonding ability for various medicines, controlled release drug delivery properties & mild framework of the research, significant attention has been paid to development of nano-particles that are SF-based for delivery of medicine. SF is generally a protein polymer which is obtained naturally with several unique properties making it an appropriate substance for inclusion within a wide range of delivery-automobiles which has ability of providing several varieties of treatment. The adjusted or retroviral polymers dependent on SF can be designed to improve the medicinal effectiveness of drugs found in this nano substance by modifying the particle size, chemical composition and properties. These were utilized for providing tiny polymers medicines (e.g., medicine for cancer treatment), growth factor medicines & protein, gene drugs, and so on. This paper examines recent developments in Nano-particles focused on SF including chemical composition, structures, and methods of preparation. Additionally, the uses of Nano-particles dependent on SF in form of catalysts of medicines which were studied.