The fundamental idea in the development of FDT is to use superdisintegrants which help tablet to immediately disintegrate when place on tongue and allow to release the drug into saliva. Through the application of superdisintegrants, fast dissolving tablets are swiftly dissolved or disintegrated. The solubility speed of the drug product impacts the absorption rate. The faster the medication dosage form dissolves in solution, the faster the clinical action is absorbed and started. In FDT, ideally a drug or dosage form should dissolve or disintegrate within 60 seconds in the saliva. The goal of this study was to use natural disintegrants to make a fast-disintegrating tablet of Atenolol. Microcrystalline cellulose was used as a diluent, aspartame was used as a sweetener, and Natural super disintegrant was used to make the tablets. Isapghula mucilage and banana powder were utilised as superdisintegrants in this investigation. In this formulation, natural superdisintegrant were employedin 2%, 4%, 6%, and 8% concentration. Based on the findings, it can be stated that the tablet formulation containing 6% Isapghula mucilage (i.e., 12 mg in each tablet, formulation code FI3) and 8% of banana powder (i.e., 16 mg in each tablet, formulation code FB4) had a faster and higher drug release viz. 98.02% and 96.75% respectively during the in-vitro dissolution study.