Online ISSN: 2515-8260

Updated Management and Prediction of Gastroesophageal Varices in Cirrhotic Patients

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Mohammed Ibrahim Ali1 , Aya Magdy Tawfik2 , Mohamed Mohamed Refaey3 , Sameh Saber Bayoumi 4 , and Ahmed F. Omar

Abstract

Background: Cirrhosis is a condition that result from chronic liver disease, and is characterized by advanced fibrosis, scarring, and formation of regenerative nodules leading to architectural distortion. Patients with cirrhosis are at increased risk of numerous complications that can occur secondary to portal hypertension, abnormal liver synthetic function, or combination of both. Portal hypertension (PH) is an increase in portal pressure beyond the threshold of 10 mmHg (clinically significant portal hypertension, CSPH) increases the risk of gastroesophageal varices (GEVs). Gastroesophageal varices (GEV) are the most relevant porto-systemic collaterals resulting from clinically significant portal hypertension, for which the presence of EV is an independent predictor of mortality. Variceal bleeding is one of the most fatal complications of portal hypertension which caused by rupture of gastric and mainly OV with a mortality rate of 17% to 57%. Non-invasive predication of varices in cirrhotic patients is useful as generalized screening of all cirrhotic patients by endoscopy would increase the work load of endoscopy units.

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