The goal of this artwork is to discover and compile the most common, everyday problems that happen during pellet production. Significant difficulties in recognising aspects starting with raw cloth homes and continuing through the pelletization's final drying process. On this evaluation, the difficult problems relating to the physical and chemical properties, interactions between drugs and excipients, and the effects of raw material type, grade, and quantity on pellet properties are covered. The emphasis is also placed on technological and process-related challenging conditions in the common used pelletization ideas, as well as extrusion-spheronization, warm-soften extrusion, and stacking processes. The research also provides insight into practical methods for addressing pellets' exceptionalities at various stages of development.