As a common entity, throat pain or sore throat is related chiefly to various infective pathologies, viral (lately COVID), bacterial or fungal. When these are treated with no relief for the same, endoscopic procedures and imaging modalities like USG, CT Scan, MRI etc. are ordered to detect the occult diagnosis .Our study included 51 participants, 20 females and 31 males, primarily complaining of throat pain with few other mild symptoms. Here we discuss not so commonly thought of entities pertaining to head and neck pathologies and few thoracoabdominal lesions detected by various imaging modes like MRI,CT and virtual endoscopy, Endoscopy, USG and X Ray Barium studies. Anatomic variants to potentially serious diseases were reported. A strong clinical suspicion and customized mode of imaging assisted in arriving to a definitive diagnosis