This study assesses the difference between Minimally Invasive Transforaminal Lumbar Interbody Fusion (MI-TLIF) surgery and conventional open TLIF surgery incases of lytic spondylolisthesis regarding pain, disability, hospital stay and complications. Lytic Spondylolisthesis patients may require fusion of one or more spinal segments. The chances of achieving a successful lumbar spinal fusion have increased. TLIF technique is gradually being accepted in these cases and widely used by most spinesurgeons. Minimally invasive TLIF is a recent trend for spinal fusion. This is a prospective randomized comparative study conducted from March 2016 to December 2018 that included 40 patients with low grade lytic spondylolisthesis who underwent TLIF. 20 patients underwent MI-TLIF through percutaneous posterior lumbar pedicular screw fixation, microscopic minimally invasive transform aminal discectomy and interbody cage fusion (patients group A) and another 20 patients underwent conventional open posterior lumbar pedicular screw fixation and TLIF (control group B). In our results, bothsurgical techniques showed improvement in pain and function within 12 months (follow up period), but group A showed statistically significant improvement in pain and function in the first 3 months. Regarding blood loss, need for transfusion and hospital stay, group A showed statistically significant better results. As a conclusion, MI-TLIF is a better option in surgical management of spondylolisthesis especially in the early postoperative period.