Tobacco consumption is one of the major health problems in public health sector. Among tobacco consumption smoking is a leading preventable cause of death in developed as well as developing countries. Cigarette smoking contributes to oral as well as general health issues including Asthma, COPD and Cancer. A dynamic comprehensive approach is required for breaking the habit of tobacco consumption in any form. Various studies conducted in the past proposed that intensive tobacco cessation interventions involving behavioral support plays an important role in the treatment of addiction. Public health professionals can play an important role in creating awareness among people regarding the ill effects of tobacco consumption. Public health professionals can create awareness through printed materials, newspapers, magazines, media etc. Advertisement and promotion of tobacco products are needed to be banned throughout the country. Government should take initiatives at central and state level to establish tobacco cessation clinics (TCCs).In this review we discussed the efficacy of various behavioral and pharmacological medications in tobacco cessation.