Aim: The aim of this study to determine the Presentation, etiology and viral markers in children presenting with hepatitis at a Tertiary care hospital. Methods: 50 cases of acute hepatitis of age 1-13yrs were included in the study. Acute hepatitis was diagnosed on the basis of history, clinical (Jaundice, pain in upper abdomen, anorexia, nausea, vomiting, fever, pruritis, tender/non tender hepatomegaly with or without ascites and without any stigmata of chronic liver disease) and biochemical evaluation (LFT i.e. serum bilirubin, Alanine aminotransferase(ALT),Aspartate aminotransferase (AST),alkaline phosphatase(ALK), serum albumin, PT/INR). Acute liver failure was diagnosed by PT>15sec/ INR>1.5 with features of encephalopathy or PT > 20 sec/ INR > 2 regardless of presence of clinical hepatic encephalopathy.. Patients were also tested for viral markers i.e. anti HAV IgM, anti HEV IgM, HBsAg, and anti HCV.