Postoperative pain is one of the most common concern for people undergoing surgery. Preventing and treating postoperative pain is crucial to the patient's early mobilisation and well-being. Pre-emptive analgesia prevents central sensitization caused by incisional and inflammatory damage during surgery and the early postoperative period and has the potential to be more effective than a similar analgesic treatment started after surgery, reducing immediate postoperative pain and preventing the development of chronic pain by reducing altered central sensory processing[1].Pregabalin, a GABA analogue, is effective in the treatment of neuropathic pain, incisional injury and inflammatory injury. Perioperative administration of pregabalin is reported to reduce perioperative anxiety, opioid consumption and opioid related side effects[2]. Amitriptyline inhibits the neuronal reuptake of serotonin and norepinephrine which is an important physiologically to terminate transmitting activity. The inhibition of norepinephrine reuptake increases the levels of norepinephrine in the posterior grey column of spinal cord. This increased levels of norepinephrine increases basal activity of alpha 2 adrenergic receptors which increases GABA transmission among spinal interneurons thereby mediating analgesic effect. Also, the sodium channel blocking effect of amitriptyline contributes to its analgesic activity.[3]