Aim: A research comparing the effectiveness of antibiotics administered in a single dosage with those administered over the course of five days in clean surgery. Material and methods: The Department of General Surgery was responsible for carrying out this research. A total of 200 patients were chosen. At the time of induction or thirty minutes before the skin incision, a single dosage of one gramme (g) of injectable cefotaxime was administered to each and every patient in the research group. They were not given any further antibiotic treatment, either intravenously or orally. In the second group, every single patient was given 1 gramme of cefotaxime intravenously BD for a period of five days. Patients who were either underweight or obese had their dosage modified such that it was proportional to their body weight. Tab. cefixime 200mg BD was administered to patients in the control group who had had laparoscopic cholecystectomy and were expected to be released in two to three days. Results: It was determined that the majority of patients were admitted for hernioplasty, which accounted for 45% of patients in the study group and 47% of patients in the control group. Laparoscopic cholecystectomy, which accounted for 39% of patients in both groups, was the next most common type of surgery, followed by appendicectomy and other surgeries. The laboratory confirmed that the main growth in the surgical site was E. coli, Staphylococcal aureus, and Streptococcal. This was the case in the control group, in which participants or patients received postoperative 3-4days of conventional antibiotic cover. However, 7 patients displayed organisms from their pus or contaminated wound, albeit in a lesser amount. While a considerable number of patients tested positive for the presence of infections, this connection was not determined to be significant. 93 percent of patients in the study group and 91 percent of patients in the control group did not have wound discharge, according to the distribution of participants among the study and control groups in terms of wound discharge. Seven patients in the study group had wound discharge, while nine patients in the control group did. Although there were more patients in the control group who had wound discharge, this difference did not show any significant association. Conclusion: Because there was no difference found in SSI whether using single dose preoperative antibiotic prophylaxis or using five days of conventional postoperative antibiotic therapy, we came to the conclusion that a single dose of antibiotic prophylaxis was sufficient for clean and clean contaminated surgeries. This was due to the fact that there was no difference found in SSI when either method was used.