Background: Snake bite envenomation is a common, acute life threatening medical emergency in India. The persons at greatest risk are farmers and agriculture laborers. Bush cleaners, construction workers, scientists and entertainers who handle the snake are also at increased risk. Snake bite is predominantly rural and occupational hazard of farmers and land workers. Snake bite is completely treatable if treated in time. The present study was undertaken to evaluate the effect of snake envenomation on cardiovascular profile. Method: Total 100 patients of more than 14 years old of confirmed case of snake bite were taken in this study excluding patients having ischemic heart disease, diabetes, valvular heart disease, known history of cardiomyopathy, deep vein thrombosis. All patients underwent physical examination, electrocardiogram, echo-cardiography, arterio-venous color doppler study and cardiac enzymes. Result: Total 100 cases had envenomation. Most common ECG manifestation showed sinus tachycardia 65% followed by 25% patients have normal ECG finding, 12% ST-T changes due to myocardial injury, 7% had bradycardia only 2% patients have noted A-V block.8 ).7Most of the echocardiographic findings are normal. Only 9% patients have global hypokinesia. Increase CPK-MB level seen in 5% cases. Increased troponin-I level seen in 12% cases. Conclusion: Cardiac complications are not prominent features of snake bite and the clinical picture is usually dominated by neurological, hematological and vascular damage by snake bite toxin. Most common cardiac manifestation in ECG was sinus tachycardia may be due to anxiety, followed by sinus bradycardia. Some patients developed myocarditic changes which were detected by serial ECG. Increase CPK-MB level seen in 5% cases. Increased troponin-I level seen in 12% cases. Most common echocardiographic finding was global hypokinesia.