Poor glycemic control was seen in most of the patients suffering with type 2 diabetes mellitus. Fixed dose combination of Metformin, Glimepiride, and Voglibose prescribed in patients with HbA1c more that 9.0% diabetic patients. the main is to study the effect of triple drug combination therapy in treating type 2 diabetes mellitus patients. Aim: To study the effect of metformin + glimepiride + voglibose in the treatment of type 2 diabetes mellitus patients. Material and methods: the present study was carried out on 200 type 2 diabetes mellitus. Patients under inclusion criteria and ready to give informed consent forms were included in the study and treated with the combination of metformin + glimepiride +voglibose. All the patients’ blood glucose levels and lipid profiles were estimated before taking drugs (baseline) and after 6 months of treatment, all the investigations were done again (after 6 months). Results: Total number of patients included in the study was 200, among them; majorities were male with the age group of 51 – 60 years. All the patients HbA1c, FBS, PPBS, total cholesterol, triglycerides, HDL, LDL & VLDL. A higher Significant mean reduction was observed in HbA1c, FBS & PPBS (p