Background: Gout is a type of arthritic disease correlated with several pains, stiffness and swelling of one or more joints. This disease can be diagnosed by testing synovial fluid, uric acid levels etc. the most commonly prescribed drug were probenecid, allopurinol, feburostat and NSAIDs. The main aim of the study is to detect whether allopurinol and probenecid shows efficiency in treating CVD patients with gout. Aim: to study the effect of allopurinol and probenecid in gouty arthritis with CVD in tertiary care hospital. Material and Method: The present study was conducted on 100 gout patients. All the patients were equally divided into two groups; group -1, 50 patients were treated with allopurinol and group 2, 50 patients treated with probenecid. All this patients monitored with symptoms and also tested with blood pressure, serum creatinine, blood urea, and blood uric acid. Results: In our study male are more compared with female with a age group of 66 – 70 year in both group 1 & 2. Gout is mostly seen at ankle with swelling as a symptom followed by pain in both the groups. After 3 months of treatment in group 1 significant was observed in uric acid values, but in group 2 both uric acid and urea are shown significant. On comparing both the groups after 3 months uric acid levels shows significant difference between group 1 and 2 respectively. Conclusion: probenecid is the better drug of choice when compared with that of allopurinol in controlling uric acid levels in gouty arthritis.