Online ISSN: 2515-8260

To study the correlation of venous blood lactate level and 6 minute walk test in stable COPD Patients in tertiary health care centre

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1Dr. Sudarshan Gupta, 2Dr. Manjul Kumar Bajpayee, 3Dr. Abhijeet Khandelwal, 4Dr. Sunil Manohar Singh, 5Dr. Gyan Prakash Verma, 6Dr. Nasir Khan, 7Dr. Srishti Gour

Abstract

Aim: To study the correlation of venous blood lactate level and 6 minute walk test in stable COPD Patients in tertiary health care centre Materials & methods: Study was conducted on 50 patients from the Department of Respiratory Medicine at Index Medical College, Research centre and Hospital, Indore and all the tests was perform with due permission from the Institutional Ethical Committee and informed consent from the subjects or their legal relatives. Subjects was included on the basis of their diagnosis of COPD as per GOLD guidelines & laboratory test of venous blood lactate level. Result: Fifty participants were recruited and 74% of them were male. The median age of all the participants was 60.48 years.Based on the Severity classification, 12(24%) of them were mild, 21(42%) moderate, 7(14%) severe and 10(20%) very severe.The participants were under regular treatment. The median of 6MWT was 280.00 m (IQR 67-53.25, 375–205 m). For Normal Lactic acid the Mean 6MWT was 336.75 mtrs for 12 samples of Group A of COPD Severity Group, 20 of Group B, 4 of Group C & 1 of Group D. For Abnormal Lactic acid the Mean 6MWT was 171.92 mtrs for 0 samples of Group A of COPD Severity Group, 1 of Group B, 3 of Group C & 9 of Group D. Conclusion: In conclusion, in COPD patients 6MWT is useful test to assess severity of disease. Our study has shown that 6MWT correlates well with pulmonary function and quality of life in patients with COPD. 6MWT can be used as a novel index in the evaluation of functional status of COPD. More importantly, steps might give additional indication in addition to distance traveled about the risk of lung hyperinflation. Considerably more work will be needed to investigate the link between steps and hyperinflation in patients with COPD.

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