Background&Method: This is a retrospective study carried out with an aim to study the concentration of anti-B2GPI (IgG and IgMisotypes) in patients with collagen vascular diseases (auto-immune disorders), pregnancy related complication and thromboembolic disorders, in patients who were tested for anti-B2GPI (IgG and IgM) and ACL (IgG and IgM) by the standardized solid-phase enzyme linked immunosorbent assay (ELISA) in pathology department. Result:The 38 patients with SLE presented with common clinical manifestations of SLE. In addition, Raynaud’s phenomenon (n = 3) and photosensitivity (n = 4) were seen in a few. Further, two each of patients with SLE had auto-immune hemolytic anemia, and history of spontaneous abortions respectively. One of the two patients with spontaneous abortions had a past history of a vertebrobasilar infarct. Renal involvement was noted in 13 (34.2%) cases, out of which 11 had biopsy proven lupus nephritis, one case had mild mesangial proliferation and in one ultrasound of the abdomen had shown medical renal disease. One patient had a clinical diagnosis of deep vein thrombosis however results of radiological tests for confirmation if done were not available. One other patient had pulmonary hypertension. The patient with primary APS had presented with seizures and post-ictal confusion. Conclusion:In present study ACL (IG & or IgM) was noted to be more prevalent than antiB2GPI (IG & or IgM) in patients with collagen vascular diseases (auto-immune diseases) and thromboembolic disorders while they showed a similar prevalence in patients with recurrent fetal losses. While we observed that there were certain differences in the prevalence of these antibodies when compared to other published studies, this could be related to differences in patient selection.