Aims & Objectives: Millions of people have low back pain, which causes more disability than any other health condition. The present study was planned for comparing the functional outcomes between pregabalin versus gabapentin in Cases of Low Back Ache with radiculopathy. Materials & methods: A total of 100 subjects with presence of low back ache with radiculopathy were enrolled. Clinical and MRI examination of all the patients was done. All the 100 patients were divided into two study groups with 50 patients in each group as follows: Gabapentin group and Pregabalin group. Capsule pregabalin 75 mg one time a dayorally and tablet gabapentin 300 mg one timea day was given in the respective groups. Both drugs were given at night time. Pain intensity was assessed at the start of study i.e. at baseline (0 week), at 1 month and three months using VAS. Complications were recorded on each visit. All the results were recorded and analysed by SPSS software. Results: Mean VAS at baseline, one month and three months among patients of group Pregabalin was 8.91, 6.96 and 3.16 respectively. Mean VAS at baseline, one month and three months among patients of group Gabapentin was 8.12, 6.43 and 3.58 respectively. While making intra-group comparison, significant results were obtained. However; while comparing the mean VAS between the two study groups, non-significant results were obtained at different time intervals. Sedation as a side effect was significantly more common in Pregabalin group. Conclusion: Gabapentin was better in comparison to pregabalin in having fewer side effects.