Objectives: The objectives were to study the clinical, biochemical and hematological profile in Plasmodium vivax malaria in F.H. Medical college Ethmadpur Agra. Results From the total patients of 240 severe disease present in 106 cases 78% of cases were having malaria for the first time. Fever present in 100% of patients, headache in 46%, jaundice present in 39%, nausea/vomiting in37.5%, pain in abdomen in 14.5%, oliguria present in 18.5% patients,4.5% patients were had petechiae/bleeding. 19.5 % patients were had parasitaemia between 25000-150000. Thrombocytopenia was most common haematological complication present almost in 75% patients which were normalised after treatment. TLC was low (<4000/cm2 ) in 45 cases which was increased to normal after treatment. Severe anaemia (Hb<7%) present in 38 patients out of which 24 patients was female. 63 patients were had serum creatinine ≥3mg/dl (30 male and 33 females), High bilirubin (>3mg/dl) was present in 74 patients out of which 24 were females and 50 males. The bilirubin level >10mg/dl was present in 8 patient out which 3 were male and 5 female. Conclusion Malaria due to Plasmodium vivax can cause severe disease with renal, cerebral, hepatic, involvement occurs with increasing frequency anaemia and thrombocytopenia is very common in vivax malaria so vivax malaria no longer is benign condition.