Abstract: Background & Method: The aim of this study is to observe the effect of oral melatonin premedication on induction doses of propofol and pentothal sodium. The patients was examined clinically a day before the surgery to note demographic data, baseline heart rate, blood pressure, respiratory rate, oxygen saturation of Hb. Biochemical tests were done to rule out co-morbid condition associated. ECG and X –Ray chest was done ASA grade 1 and 2 patients of either gender, 18 - 60 years old, scheduled to undergo elective surgical procedures under general anesthesia will be assigned into equal groups- group (P+M), group (P), group (PS+M) and group (PS). Result: In P Group, the mean Pulse 120 minutes after drugs (mean± s.d.) of patients was 91.6774± 11.5741. In P + M Group, the mean Pulse 120 minutes after drugs (mean± s.d.) of patients was 82.0968± 7.4938. In PS Group, the mean Pulse 120 minutes after drugs (mean± s.d.) of patients was 90.1613± 10.2538. In PS + M Group, the mean Pulse 120 minutes after drugs (mean± s.d.) of patients was 80.4516± 7.9282. Distribution of mean Pulse 120 minutes after drugs with Group was statistically significant (p=<0.0001). In P Group, the mean MAP 120 minutes after drugs (mean± s.d.) of patients was 99.9677± 6.4626. In P + M Group, the mean MAP 120 minutes after drugs (mean± s.d.) of patients was 89.1290± 7.4420. In PS Group, the mean MAP 120 minutes after drugs (mean± s.d.) of patients was 100.0000± 7.0475. In PS + M Group, the mean MAP 120 minutes after drugs (mean± s.d.) of patients was 86.0968± 8.0056. Distribution of mean MAP 120 minutes after drugs with Group was statistically significant (p=<0.0001). In P Group, the mean Dose calculated as mg/kg (mean± s.d.) of patients was 1.9529± .1710. In P + M Group, the mean Dose calculated as mg/kg (mean± s.d.) of patients was 1.0932± .0754. In PS Group, the mean Dose calculated as mg/kg (mean± s.d.) of patients was 4.6161± .3666. In PS + M Group, the mean Dose calculated as mg/kg (mean± s.d.) of patients was 2.6835± .3678. Distribution of mean Dose calculated as mg/kg with Group was statistically significant (p=<0.0001). In P Group, the mean Dose required (mg) (mean± s.d.) of patients was 107.7419± 19.0979. In P + M Group, the mean Dose required (mg)(mean± s.d.) of patients was 72.2581± 14.3084. In PS Group, the mean Dose required (mg) (mean± s.d.) of patients was 295.1613± 40.5274. In PS + M Group, the mean Dose required (mg) (mean± s.d.) of patients was 186.2903± 42.7389. Distribution of mean Dose required (mg) with Group was statistically significant (p=<0.0001).