Background&Method: This study is done with an aim to find out any correlation between the measured biochemical parameters in patients with CRF. In this study, 200 people over the age of 20 including both sexes who had chronic renal failure were selected. These patients (subjects) were attending OPD and admitted to the ward of general medicine. In addition, 200 normal healthy individuals (control) over the age of 20, staff members, patient attendants, and volunteers were included as controls. The patients were diagnosed as chronic renal failure by the department of general medicine at index medical college hospital and research centreindore (MP) and Amaltas institute of medical sciences, Dewas (MP). Result:Correlation between Urea and HS-CRP. We have found a significant positive correlation between both parameters. Correlation between Urea and Total Cholesterol. we have found a significant positive correlation between both parameters. Correlation between Urea and Homocysteine. we have found a significant positive correlation between both parameters. Conclusion:The mean serum concentration of IL-6 of CRF patients was high (25.38±17.20) in comparison of healthy control mean (2.15 ± 1.03). It has been found that the difference between them was also statistically significant p-value is <0.001. The mean serum concentration Hs-CRP of CRF patients was high (12.09±3.78) in comparison of healthy control mean (1.03 ± 0.12). It has been found that the difference between them was also statistically significant p-value is <0.001. It should be enrolled a large number of patients. It should be cohort study with follow up of patients’ clinical conditions for better establishment of these markers.