Background: Significant postoperative discomfort is a side effect of total knee arthroplasty (TKA), which restricts postoperative movement, which is essential for restoring joint function. Pain is possibly the most dreaded thing in the world. It warns the body of illness. The intensity and length have an effect on quality of life. In orthopaedics, pain following total knee arthroplasty (TKA) is a major concern. Although continuous epidural analgesia and opioids continue to be the main options for postoperative pain treatment following TKA, they have negative side effects include drowsiness, nausea, and hypotension. An intricate and technically challenging technique requiring close monitoring is epidural catheterization. Local anaesthetic solution infiltration significantly reduces pain at the site. The learning curve is minimal, there are no long-term negative effects, no infections, no motor block at all, early mobilisation, and cost effectiveAn intricate and technically challenging technique requiring close monitoring is epidural catheterization. Local anaesthetic solution infiltration significantly reduces pain at the site. It has a minimal learning curve, no infection, no systemic side effects, no motor block at any level, early mobilisation, and is cost-effective. The use of ropivacaine and clonidine together as a LIA has not been extensively studied. Methodology: At a tertiary care facility, a prospective study was conducted on 40 patients having total knee replacement surgery. A thorough evaluation of the airway, respiratory system, and cardiovascular system was done during the pre-anesthesia check-up. The simplest laboratory data were examined. The VAS was explained to patients, and it was assessed before surgery while the operated-on knee was at rest and while it was moving. Results & Conclusion: The average age was 63.45 + 8.6 years, as we saw. Thirteen (32.5%) of the 40 patients were male, and 27 (67.5%) were female. In the first 24 hours following total knee replacement surgery, ropivacaine and clonidine have proven to be particularly efficient painkillers. We came to the conclusion that the need for opioid has diminished with the use of local infiltrative anaesthetic, or the combination of ropivacaine and clonidine. Tachycardia and hypertension effects on the cardiovascular system have also diminished. Early mobilisation also helped the patient, who benefited.