Background&Method: The study was conducted with aim to evaluate and compare the efficacy of IV esmolol and IV lignocaine in blunting the hemodynamic response to laryngoscopy and intubationsat Sanjay Gandhi Medical College, Rewa, M.P. In the operating room the patients was transferred to the operating table. An intravenous infusion with saline 0.9% was started using 18 G cannula in a peripheral vein. Blood pressure monitored by manual cuff. A pulse oximeter was placed on the finger. ECG monitoring was also established. A central venous line placed in the cubital vein using a 375 cava fix and a 0.9% normal saline was started. Baseline heart rate and blood pressure were recorded. Random allocation of patients to each group was done lots drawn by a person not taking part in the study. The investigator that is the person doing the study was unaware of the drug used. Result: The difference between the groups in distribution of age (p=0.6), weight (p=0.7) and sex ( p=0.8) were not statistically significant. In duration of laryngoscopy and intubations was not statistically significant. (P=0.5).In grades of laryngoscope was not statistically significant (P= 0.51). In experience of anesthetist was not statistically significant. (P=0.37). Conclusion: Esmolol and lignocaine are both similar in their effectiveness in attenuating the haemodynamic response to laryngoscopy and intubation’s, but they do not abolish it completely. More studies need to be carried out to confirm the perception that esmolol in combination with the newer narcotic agents like fentanyl may abolish the haemodynamic response to laryngoscopy and intubations, particularly required in the patients in whom a single hyper dynamic response may be catastrophic.