Aim and objective: the aim of the present study was to determine the prescription pattern of drugs used in myocardial infarction in Bihar region. Material and methods: This was a Retrospective observational and analytical study was done in the Department of Medicine, Anugrah Narayan Magadh Medical College and Hospital, Gaya, Bihar for one Year. Total 100 patients were included in this study. The data from the case records of all patients admitted to hospital with a diagnosis of AMI during study period. Results: Total 100 patients case paper were analysed during one year study period. Results pointed out that the frequency of myocardial infarction was more in male patients (62%) than female patients (38%). As far as age factor is concerned 42% patients belong to age group 50-60 yrs and 39% patients belong to 60-70 yrs. In our study, average hospital stay was found 6.21 days. Average ICU stay was 1.88 days and that of medicine ward was 4.1 days. The percentage of prescription pattern of various classes of drugs was for Antiplatelet Agents (92%), Antianginal drugs (65%), Hypolipidemics (62%), Beta receptor antagonist (35%), Angiotensin Converting Enzyme Inhibitors (ACEI) (31%) , Diuretics (24%) , Anticoagulants (16%), Calcium Channel Blockers (CCBs) (14%), Angiotensin Receptor Blockers (ARBs) (13%), NSAID's (7%) and Bronchodilators (2%) drugs respectively. Most of the patients received Aspirin as well as Clopidogrel. Conclusion: Antiplatelet drugs were the most commonly prescribed and alpha blockers were prescribed least as evident from our study.