Aim: The aim of the study to analyse the thyroid profile, hs-CRP and lipid profile in newly detected hypothyroid adults in comparison to controls and also to compare the above parameters in subclinical and clinical hypothyroid cases. Methods: The study was a cross sectional study which was carried in the Department of Medicine ,Darbhanga Medical College and Hospital, Laheriasarai, Darbhanga,Bihar,India. for 1 year. Total 180 patients were divided into 2 groups. Group-1 for newly detected hypothyroid adults and Group 2 as Controls. Blood samples were collected with full aseptic precautions after obtaining informed consent. Clot activator that contains vacuum evacuated tubes for analysis of serum TSH, FT3, FT4, TC, HDL-c, LDL-c, TG, hs-CRP. Then after collection, serum samples were stored at -200 until analyzed. Anthropometric measurements for BMI, height (cm) and body weight (kg) were measured. Results: The mean age of cases and controls in our study was found to be 36.32±12.31years and 35.97±11.16 years respectively (p=0.67). Approximately 83.33% of cases and 71.11% of controls were females depicting a female preponderance. BMI values in the study were higher in cases (26.89± 4.87kg/m2) compared to controls (24.77± 4.56kg/m2) and was statistically significant (P=0.03). The mean TSH levels (14.77 ± 9.8µIU/ml) of cases were high compared to controls (4.2 ± 0.91µIU/ml) and was statistically significant (p < 0.001) The total cholesterol level in cases (183.31 ± 40.77mg/dl) and control (187.32±28.38mg/dl) were within the reference range and there was no statistical significance (p=0.79). HDL-c in cases (48.29±9.37mg/dl) and control (52.57±6.6mg/dl) were found to be lower in cases compared to controls and the difference was statistically significant (p < 0.001). The mean LDLc value in cases (145.14±34.12mg/dl) and control (134.05±31.14mg/dl) was high in cases and the difference was statistically significant (p=0.01). The triglyceride levels of cases (158.27±49.87mg/dl) were significantly higher than that of control (145.24±27.27mg/dl) and was statistically significant (p=0.02). As per the Pearson’s correlation, there was a significant positive correlation between serum TSH and hs - CRP levels in cases (r=0.237, p < 0.001). Conclusion: The hypertriglyceridemia and at risk hs-CRP levels though seen in hypothyroid cases were more prominent in CH cases than SCH. Dyslipidemia and inflammatory markers were found to be increased in the cases that helped in prediction and evaluation of patients at risk of cardiovascular disease.