Background: Laryngoscopy and intubation induce huge spectrum of stress responses such as tachycardia and hypertension. Those are in association with the surge of plasma adrenaline concentration following intubation. This study was performed to compare the efficacy of an accurate bolus dose of esmolol and bolus dose of dexmedetomidine in attenuating the pressor response to laryngoscopy and endotracheal intubation in general anaesthesia.