Aim: To Compare the Effectiveness of Bupivacaine Versus Levobupivacaine in Supraclavicular Brachial Plexus Block. Material and methods: This cross sectional comparative study conducted on 100 patients of ASA I & II status in the age group of 20-58 years given brachial plexus block by supraclavicular approach for various upper limb surgeries, were included in this study. Result: There was no statistically significant difference between two groups in demographic data i.e. age, gender, weight, ASA status. The mean onset time of sensory block was 11.98 minutes in group B & 10.03 minutes in group L while the mean onset time of motor block was 13.9 minutes in group B & 12.01 in group L. Mean onset time of sensory and motor block were significantly shorter in group L than in group B. The mean duration of sensory block was 878.88±118.55 minutes in group B & 1029.35±139.77 minutes in group L while the mean duration of motor block was 929.55±108.58 minutes in group B & 1111.11±138.65 minutes in group L Mean duration of sensory and motor block are significantly longer in group L that in group B. The mean duration of analgesia was 911±118.27 minutes in group B and 1068.69±151.47 minutes in group L . The mean duration of analgesia was significantly prolonged in group L compared to group B. Conclusion: We concluded that levobupivacaine has a faster onset of both sensory and motor blockade as compared to racemic bupivacaine. Also, the duration of both sensory and motor block is longer with levobupivacaine.