Introduction: Laparoscopic surgeries has revolutionized abdominal surgeries, however, this procedure is not risk free. Hence, the present study was designed to evaluate the efficacy of dexmedetomidine versus clonidine in prevention of such hemodynamic changes. Materials and Method: 60 patients of age group 20 to 60 years, of ASA grade I & II were selected and divided into two groups (each group containing 30 patients); group I Inj. Dexmedetomidine 2 mcg /kg IV was administered and in group II Inj. Clonidine 2 mcg /kg IV was administered. All 60 patients were intubated with cuffed endotracheal tube of appropriate size. All vital data (PR, NIBP, RR, SPO2, temp) were recorded. Pulse rate, blood pressure, SPO2, EtCO2 before and after intubation and throughout surgery was observed and recorded. Statistical analysis was done using student’s ‘t’ test and Chi-square test, result considered significant if p value <0.05.