Introduction: Overweight was defined as a BMI ≥23 kg/m2 but <25 kg/m2 for both genders (based on the World Health Organization Asia Pacific Guidelines) with or without Abdominal Obesity (AO). Generalized Obesity (GO) was defined as a BMI ≥ 25 kg/m2 for both genders (based on the World Health Organization Asia Pacific Guidelines) with or without AO. Ghrelin is synthesized as a pre-prohormone, in the epithelial cells lining the fundus of the stomach, with smaller amounts produced in the placenta, kidney, pituitary and hypothalamus. Ghrelin is an appetite-stimulating hormone that increases growth hormone secretion and food intake in humans. Furthermore, ghrelin regulates several physiological processes, including glucose metabolism, insulin secretion, gastric emptying, cell proliferation, learning and memory, stress and anxiety. Material and Methods: All the obese patients attending outpatient department (OPD) of Medicine. Subjects willing to participate and written informed consent was obtained from each participant before study. Subjects were screened for selection criteria. Baseline evaluation included recording of demographic details, BMI, medical history, general and systemic examination and laboratory investigations, which included complete haemogram, hepatic and renal function tests and routine urine analysis. The eligible patients were enrolled as randomization. Metformin was given at a daily dose of 1.0 gm BD for 3 months. Followup visits were scheduled at the end of every month for 3 months for assessment, including measurement of weight and general and systemic examination.