Background- The most probableoutcomes in temporomandibular joint disorders (TMDs) is intense pain, inflammation of the underlying muscles, posterior fibers, and synovial fluid, restricted mouth opening, unbalanced jaw movements, and sounds.The aim of present study was to assess and compare the effectiveness of ultrasound heat therapy and low-level laser therapy (LLLT) on TMD-related pain reduction. Methodology-There were 42 patients (age range, 25-45 years) in this prospective study, categorized into two groups 21 participants of each. A NSAID medication was advised to all participants twice a day for 5 days for momentary pain control before starting of therapy.Participants were maintained on a soft diet and were advised to limit the opening of their mouths during the same time. The affected side underwent 15 sessions of LLLT (Group A) or ultrasound therapy (Group B). Results- The mean visual analog scale scores for groups A and B were 4.81 (2.01) and 6.19 (1.20) individually, at the end of therapy; the difference was statistically significant, favouring the LLLT group. Likewise, for group A and group B, the mean mouth opening was 3.99 (0.40) and 3.65 (0.41), in both; the difference was significant statically and the LLLT group was preferred. Conclusion- For the treatment of TMD-related pain without underlying bony pathology, present study recommends LLLT.