The use of the latest technology in radiation therapy for prostate cancer treatment by (VMAT-SIB and IMRT-SIB) methods is conducted with using 3D in treatment planning. The purpose of this study is to calculation done the total radiation doses by linear quadratic model (LQ). Mainly, the study objective is to a comparative analysis of methods of irradiation of prostate cancer. Use highly radiation doses for prostate cancer treatment while keeping normal cells (rectum, bladder, left femur, right femur, and bones) safe from highly radiation doses. The study of seven prostate cancer patients was conducted. The first patient had done prostate cancer treatment in two sessions by VMAT-SIB and IMRT-SIB methods and use a 9-field sliding window IMRT technique. The second patient had done prostate cancer treatment in three sessions by VMAT-SIB and IMRT-SIB methods and use a 4- field sliding window IMRT technique. Calculation of radiation doses was carried out for four patients. We done radiation treatment planning work to the patient with prostate cancer by 3D technique and using (VMAT-SIB and IMRT-SIB) methods. Total radiation doses (48.000GY). Calculate was done total radiation doses (minimum dose, maximum dose, mean dose, and other doses) for each normal tissues are (rectum, bladder, left femur, right femur, and bones) in stage the prostate cancer prostate treatment. The VMAT-SIB and IMRT-SIB) methods are more effective treatment, increased higher total radiation doses, shorter total treatment time, and at the same time had low side effects on normal tissues.