COVID-19 has devastated healthcare systems all over the world and is still raging in Italy. In many countries, patients with chronic illnesses are suffering from delay in diagnostic and treatment management. We report a challenging case of a HIV patient who experienced delay in diagnosis of multiple myeloma due to COVID-19 pandemic restrictions. Global cooperation to ensure equity and responsiveness to local contexts is essential on the difficult path ahead to ending the COVID-19 pandemic, as treatment for one potentially curable disease should not be performed at the expense of another.