1. INTRODUCTION Craniocerebral injury (CCI) is an urgent problem accounting for 35-40% of all injuries in peacetime. In associated injuries, the CCI proportion reaches 70-72%. Clinical and neurological symptoms in CCI in general and in post-traumatic skull defects in particular are varied. These patients have cerebral, focal, vegetative-somatic symptoms, and some patients have epileptic seizures [3,4,6]. Since ancient times, doctors have been dealing with the post-traumatic defects closing and restoring the cranial vault integrity problem, and until now, researchers are developing various plasty methods of skull defects and finding the best method for fixing the graft [1,2,5]. When carrying out restorative treatment, it is optimal to eliminate or completely compensate for the damage, and with a trepanation defect in patients with severe traumatic brain injury consequences, pathogenetic therapy should be started with its plastic closure [4,8,9,10]. The optimal characteristics for any fixation system are biological material inertness, fixation reliability, lack of displacement between the graft and the cranial vault, ease of use, and moderate the construction cost, lack of artifacts during neuroimaging, neurophysiological or any other research methods. None of the known graft fixation methods to date satisfies all these requirements to a sufficient extent [7, 10, 11, 12, 13]. The skull defect presence, especially an extensive one, leads to the organic and functional disorders development of the brain structures, impaired hemo- and cerebrospinal fluid dynamics in the brain. At the same time, the danger of traumatizing an unprotected brain from the outside increases significantly [1,3,4,10]. Considering the above, in this work, we set ourselves the goal of investigating the clinical and neurological symptoms significance and assessing the using various methods effectiveness of post-traumatic cranial vault defects plasty.