Aim:The outcome of necrotizing soft tissue infection in Western UttarPradesh-A Prospective Study. Material and Methods: This study was conducted at Muzaffarnagar medical college Muzaffarnagar UP from Sept 2019to Sept 2021.50 patients with clinical features of Necrotic soft tissue infection were admitted and twice daily dressing and debridement with broad spectrum antibiotics. Results: 58 patients with features of necrotic soft tissue infection were admitted during study period showed Lower Limb Involvement (57%) followed by perianal region an scrotum(23%). Diabetes (74%) was the most common co morbidity found and was associated with increased risk of mortality, which previous studies also confirmed. In this study mean duration of admission was 24.9days.10patients died during treatment due to severe sepsis. In this study rta is the 3rd common cause of nsti during this study period(8.9%).with 40% patients healed with no need for grafting(lund and browders chart of burn). Conclusion: 40-60 years aged were most commonly involved. As the duration of stay increases the mortality tends to increase early debridement with twice daily dressing with antibiotic coverage determine the outcome of the patients with necrotic soft tissue infections.