The exocrine glands are affected by Sjögren's syndrome, a systemic autoimmune illness characterized by lymphoplasma cell infiltration.[1] reduction of glandular activity over time. A secondary form that is linked to various autoimmune illnesses exists in addition to the primary form, which affects the exocrine glands with or without systemic involvement (scleroderma, rheumatoid arthritis, systemic lupus erythematosus, and connective tissue diseases, etc.) Renal Tubular Acidosis (RTA), which can be overt or latent and is caused by tubulo-interstitial nephropathy,it is the characteristic extra-glandular sign of primary Sjögren's syndrome.[2] Salivary or lacrimal gland biopsies are used to diagnose Primary Sjogren Syndrome