Nurses are one of the most important assets affecting the efficiency and effectiveness of a hospital. The high intention of nurse turnover in a hospital can weaken the structure of the nursing system and hinder the proper implementation of the nursing processes and procedures itself. The purpose of this study was to analyze the influence of job satisfaction and stress on nurses on turnover intention. Associative and explanatory were used in this study. All of the nurses who work in Mitra Medika Hospital Medan were participants with a total sample of 126 nurses obtained using cluster sampling and random sampling techniques. The results showed that there was an influence of job satisfaction on turnover intention (p=0.000) and there was an influence of work stress on turnover intention (p=0.000). A hospital is expected to be able to manage nurses as well as possible so that nurses can increase job satisfaction to reduce turnover intentions.