Abstract The current research aimed to identify the effectiveness of self-sympathetic-based therapy. The sample of this study consisted of (30) adolescents of unknown parents who have a low degree regarding the perceived stigma. The sample was chosen on purpose. The sample was divided into two groups randomly with 15 adolescents for each one; control and experimental group. The following instruments were used in the research: Perceived Stigma Scale (developed by the researcher), Self-Sympathetic-Based Therapy Program (developed by the researcher), which included (18) sessions, it took nearly two and a half months to be applied, by two sessions per week, and a 60 minutes’ duration of each session. The results of the research indicated there are statistically significant differences at the level of significance (0.05) between the mean scores of the individuals of the two groups: the experimental and the control in the post-measurement on the perceived stigma scale in favor of the members of the experimental group. There are statistically significant differences at the level of significance (0.05) between the mean scores of the members of the experimental group in the pre and post measurement: on the scale of perceived stigma in favor of post-measurement. There were no statistically significant differences at the level of significance (0.05) between the mean scores of the members of the experimental group in the: post and tracer measurements on the scale of perceived stigma.All in all, these results indicate the effectiveness of self-sympathetic-based therapy in reducing the perceived stigma of adolescents of unknown parents deposited in residential institutions in the city of Hail; and this includes its sessions, its techniques, and various activities