Chronic obstructive pulmonary disease (COPD) is a chronic lung disease characterized by progressive non-reversible or partially reversible obstruction of airflow obstruction in the airways. This study aimed to determine the effect of a combination of upper and lower limb resistance training on respiratory rate and oxygen saturation in patients with chronic stable obstructive pulmonary disease undergoing medical rehabilitation programs. The study used a quasi-experimentaltwo-group pre-test post-test. The samples were selected by consecutive sampling technique.Data were analyzed using descriptive statistics, paired t-test and independent t-test.The mMRC scale was obtained the most at mMRC1.The frequency of patients with pulmonary function disorders in obstruction in the moderate category was 55.6% in the treatment group and 66.67% in the control group. Restrictions in the moderate category were 55.6% in the treatment group and 61.11% in the control group and the most Brinkman Index values were in the weight category of 55.6% in the treatment group and 72.22% in the control group. Respiratory frequency and oxygen saturation in the patient obtained a value of 91.38±2.25, then the oxygen saturation value decreased for a certain time to be 90.22±0.51. Whereas in the treatment group it was 92.06±2.88 while after the exercise it became 95.72±2.32. This study concludes that there is an effect of the combination of upper and lower limb resistance training on respiratory rate and oxygen saturation in patients with Chronic Stable Obstructive Pulmonary Disease.