Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the world but is projected to be the third leading cause of death in 2020. This study aimed to examine the effect of combined chest physiotherapy and Active Cycle Breathing Technique (ACBT) on oxygen saturation and respiratory rate. The research method used was a quasiexperimental approach with pre-test and post-test control group design. The sampling technique used by the researcher was purposive sampling with 60 responde nts, divided into 30 intervention groups and 30 control groups. The results obtained were there were significant differences in the respiratory rate in the control group and the intervention group after being treated with a value of p=0.001 (p <0.05). The difference in the proportion of the ability to excrete sputum in the intervention group was 7 times more productive than the control group. It is hoped that nursing practice and nursing education will increase knowledge and skills in providing chest physiotherapy and ACBT so that they can apply these actions to patients who have sputum retention problems in the airway, especially COPD patients.