Menopause indicates that a woman's menstrual and reproductive period has ended. This happens because the ovaries are aging causing the production of the hormone estrogen to decrease. A woman's body who is obese will make some estrogen in fat tissue so that fat women have estrogen levels that are higher than normal estrogen levels so that with active estrogen, women are still menstruating (late menopause). The purpose of this study was to determine the effect of obesity on the incidence of late menopause in women aged 55-65 years in the Medan Johor Health Center Work Area in 2022. The study was an observational analytic study with a case-control design. The results found that there were 34 women (69.4%) aged 55-65 years in the case group with obesity (BMI > 25). The results of bivariate analysis using the simple logistic regression test showed that there was a significant effect between obesity and late menopause where a p-value of 0.015. The conclusion is that there was an effect of obesity on the incidence of late menopause in women aged 55-65 years in the working area of the Medan Johor Health Center in 2022. The advice given is that women who have experienced menopause should carry out regular checks and maintain an ideal body weight to avoid risk factors for health problems at the age of menopause and maintain a healthy lifestyle to avoid complications after menopause.